To probes out the oxidative effects of (palm oil) on electrolytes and histo-logical alteration in mice kidney. Twenty four albino mice were distributed into three (I to III) groups consist 8 mice in every group. (Group I) was fed with common food, (FPO) (groups II) and oxidized palm oil (10HPO), (group III) were feed for a 4 weeks. Results revealed that, Group II (55.5 ± 4.04 g) and III (68.11± 9.97 g) mice gain significant (p < 0.05) body weight. Creatinine retention was prominently more noteworthy (p