The study conducted to examine influence of parental variables on the academic performance of secondary school student in biology. The population of the study consisted of all the secondary schools students’ Enugu South Local Government Area of Enugu State. The study adopted survey design, while random sampling technique was used in selecting two hundred and fifty (250) respondents. The structured questionnaire was used to elicit information from the respondents. Data collected were analyzed using percentage analysis. In conclusion, the study revealed Parental educational background, parental academic involvement, parents’ occupation and parent’s marital status influence students’ performance in biology. It was also recommended that, since parents education influences students academic achievement in Biology, the government and all stakeholders in education sector should endeavour to implement its policy on basic education for all and thus create an enlighten society in which every parent would be educated enough to have a positive influence on their children especially in their attitude towards Biology which in turn would lead to better achievement in the subject