Learning of English language has been one of the major challenges in secondary schools in Niger state. This study therefore examines the problem associated with teaching and learning of English language as a second language. Due to the fact that mother's tongue has a huge and important role to them. This study examine the impact of mother’s tongue interference on the teaching of English language as a second language, to examine the impact of language transfer on the teaching of English language as a second language, to examine the impacts of students readiness to Learn, to examine the impact of availability of resources on the teaching of English language. The population for the study consisted of junior and senior secondary students in both public and private in Niger State. The sample size of the study consisted of one hundred and fifty (150) students from five (5) secondary schools in the area of the study. This research was carried out using the survey research design with the population of 100 student in both the public and private schools in Niger state. The purposive sampling method was used to select 150 participants, majority of the respondents were females (53%) the greatest proportion of the participants (45%) were in JSS 2. A structured questionnaire titled, “the problems associated with teaching of English language as a second language in Niger state”. The research questions were analyzed using descriptive statistics while hypothesis were tested using regression analysis. To ensure validity of the instrument for this study, the questionnaire was vetted by research supervisor and other expert in the field and this covered the content validity of the instrument. The results show that there is a significant relationship between mother’s tongues interference and English language. This was treated on the basis of the hypothesis formulated for this study. It was followed by conclusion drawn from the findings along the recommendation. The study clearly reveled understanding of the problem associated with teaching of English language as a second language in secondary schools in Niger state. It concluded that mother’s tongue has an influence on the English language students. Based on the outcome of the study it was recommended that secondary students should make use of the information provided in this study through the findings to improve their learning of English language as a second language