The study examined the relationship menace of office politics on organizational effectiveness in civil service commission of nigeria. In order to carry out this study, one specified research objectives were drawn from which null hypotheses were formulated and used for the study. The research design for this study is an Expost Facto design. The population of the study consisted of 30,969 in south south and south west geo political. Simple random and stratified sampling technique was used to select 250 respondents out of the population. The instrument used for data collection was questionnaire. The instrument was validated by two experts in Test and Measurement. Crombach Alpha reliability technique was used for testing the reliability of the instrument and reliability index of .77 was realized, hence the instrument was regard as being reliable. Data from 250 completed questionnaires was subjected to PPMC and regression analysis. The findings showed that concluded that there is significant relationship office politics and organizational effectiveness of ferderal civil service commission of nigeria. The study recommeded that management and staff should avoid distorting or manipulating the truth and facts; management should be fair in their dealings; management and staff should be flexible, appreciable and accessible to others and managers and office workers should ensure a timely and open communication system.