The study examined the influence of entreprenuerial skills and management of small and medium scale businesses in Nigeria. In order to carry out this study, two specified research objectives were drawn from which null hypotheses were formulated and used for the study. The research design for this study is an Expost Facto design. The population for the study was made up of 5621 registered business operators in Ika-Ika Uqwa and Watt Market in Cross Rivers State, Oil Mill Market and Mile I Market in Rivers State, and Urua Akpan Andem, Urua Itam Market in Akwa Ibom State. Simple random sampling technique was used to select 1446 respondents out of the population. The instrument used for data collection was questionnaire. The instrument was validated by two experts in Test and Measurement. Crombach Alpha reliability technique was used for testing the reliability of the instrument and reliability index of .77 was realized, hence the instrument was regard as being reliable. Data from 1446 completed questionnaires was subjected to PPMC analysis. The findings showed and concluded that there is significant influence of entreprenuerial skills and management of small and medium scale businesses in Nigeria. Entrepreneurship training should be integrated in the tertiary institution irrespective of your course of study so that the level of business failure could be minimized whenever established. Workshops and seminars should be organized for operators of small scale business owners by the agencies responsible for the development of small scale in-depth knowledge and technical know-how on the assessed entrepreneurship skills.